Multiple Endocrine Neoplasia 2a Presenting with Pheochromocytoma and Pituitary Macroadenoma

Multiple Endocrine Neoplasia 2a Presenting with Pheochromocytoma and Pituitary Macroadenoma

Multiple Endocrine Neoplasia type 2A (MEN-2a) is a rare disease associated with tumors of endocrine organs. Presentation most commonly is with medullary thyroid cancer and infrequently with other complaints. Pituitary adenoma has been seen coincidentally with this disease very rarely. Presented is a case of coincident MEN-2a with a symptomatic pituitary adenoma and an asymptomatic pheochromocyt...

Pituitary adenoma associated with pheochromocytoma/paraganglioma: A new form of multiple endocrine neoplasia.

. Thakker RV. Calcium sensing receptor: Role in health and disease. Indian J Endocrinol Metab. 2012; Suppl 2:S213--6. . Toka HR, Pollak MR. The role of the calcium-sensign receptor in disorders of abnormal calcium handling and cardiovascular disease. Curr Opin Nephrol Hypertens. 2014;23:494--501. . Raue E, Pichl J, Dörr HG, Schnabel D, Heidemann P, Hammersen G, et al. Activating mutations in th...

Local recurrence of pheochromocytoma in multiple endocrine neoplasia type 2A: a diagnostic and therapeutic challenge

In a patient with multiple endocrine neoplasia type 2A (MEN2A), an inverted physiological ratio between urinary normetanephrines and metanephrines is an early marker of recurrence in epinephrine-secreting pheochromocytoma, and 131I MIBG treatment appears to be a useful therapeutic option in order to avoid multiple invasive surgical procedures in pheochromocytomatosis.

[Type 2A multiple endocrine neoplasia with cutaneous lichen amyloidosis].

Cutaneous lichen amyloidosis associated with multiple endocrine neoplasia type 2A.

We have previously described a kindred with hereditary medullary thyroid carcinoma and pheochromocytoma (multiple endocrine neoplasia type 2A [MEN 2A]) with localized pruritic cutaneous manifestations present only in affected members. Although the initial skin biopsies reported did not show amyloidosis, subsequent skin biopsy results reported here have demonstrated amyloid which stained for ker...